{"id":95797,"date":"2025-09-28T18:01:18","date_gmt":"2025-09-28T21:01:18","guid":{"rendered":"https:\/\/med.estrategia.com\/portal\/entidade\/hemoglobinuria-paroxistica-noturna-hpn\/"},"modified":"2025-11-09T10:51:29","modified_gmt":"2025-11-09T13:51:29","slug":"hemoglobinuria-paroxistica-noturna-hpn","status":"publish","type":"entity","link":"https:\/\/med.estrategia.com\/portal\/entidade\/hemoglobinuria-paroxistica-noturna-hpn\/","title":{"rendered":"Hemoglobin\u00faria parox\u00edstica noturna (HPN)"},"content":{"rendered":"<p>A hemoglobin&uacute;ria parox&iacute;stica noturna (HPN) &eacute; uma doen&ccedil;a adquirida das c&eacute;lulas-tronco hematopoi&eacute;ticas, de origem gen&eacute;tica, causada por uma muta&ccedil;&atilde;o som&aacute;tica no gene PIGA, localizado no cromossomo X.&nbsp;<p>Essa altera&ccedil;&atilde;o compromete a s&iacute;ntese de &acirc;ncoras GPI (glicosilfosfatidilinositol), estruturas respons&aacute;veis por fixar prote&iacute;nas reguladoras na membrana das c&eacute;lulas sangu&iacute;neas. A aus&ecirc;ncia dessas prote&iacute;nas, especialmente em eritr&oacute;citos, leuc&oacute;citos e plaquetas, torna essas c&eacute;lulas vulner&aacute;veis &agrave; a&ccedil;&atilde;o do sistema complemento, levando a consequ&ecirc;ncias sist&ecirc;micas importantes.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"A hemoglobin&uacute;ria parox&iacute;stica noturna (HPN) &eacute; uma doen&ccedil;a adquirida das c&eacute;lulas-tronco hematopoi&eacute;ticas, de origem gen&eacute;tica, causada por uma&hellip;\n","protected":false},"author":33,"featured_media":100148,"comment_status":"closed","ping_status":"closed","template":"","meta":{"wl_entities_gutenberg":"","footnotes":""},"categories":[],"wl_entity_type":[191],"class_list":{"0":"post-95797","1":"entity","2":"type-entity","3":"status-publish","4":"has-post-thumbnail","6":"wl_entity_type-thing"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hemoglobin\u00faria parox\u00edstica noturna (HPN) - 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