{"id":108583,"date":"2026-03-23T17:52:27","date_gmt":"2026-03-23T20:52:27","guid":{"rendered":"https:\/\/med.estrategia.com\/portal\/?p=108583"},"modified":"2026-03-31T11:16:18","modified_gmt":"2026-03-31T14:16:18","slug":"resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais","status":"publish","type":"post","link":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/","title":{"rendered":"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!"},"content":{"rendered":"<p><strong>Ol&aacute;, querido doutor e doutora!<\/strong> A <strong>Doxi-PEP<\/strong> representa uma estrat&eacute;gia de profilaxia p&oacute;s-exposi&ccedil;&atilde;o voltada &agrave; redu&ccedil;&atilde;o de infec&ccedil;&otilde;es sexualmente transmiss&iacute;veis bacterianas em popula&ccedil;&otilde;es selecionadas. A incorpora&ccedil;&atilde;o dessa abordagem demanda tamb&eacute;m aten&ccedil;&atilde;o ao risco de resist&ecirc;ncia e &agrave; necessidade de seguimento peri&oacute;dico.<p><em>A administra&ccedil;&atilde;o deve ser realizada idealmente at&eacute; 24 horas ap&oacute;s a exposi&ccedil;&atilde;o, podendo ser utilizada em at&eacute; 72 horas.<\/em><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_79_2 counter-hierarchy ez-toc-counter ez-toc-transparent ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\"><p class=\"ez-toc-title\" style=\"cursor:inherit\">Navegue pelo conte\u00fado<\/p>\n<\/div><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Visao-geral\" >Vis&atilde;o geral<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Indicacoes-e-dosagem\" >Indica&ccedil;&otilde;es e dosagem<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Indicacoes\" >Indica&ccedil;&otilde;es<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Dosagem-e-Administracao\" >Dosagem e Administra&ccedil;&atilde;o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Posologia\" >Posologia<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Limite-de-dose\" >Limite de dose<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Frequencia-de-uso\" >Frequ&ecirc;ncia de uso<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Situacoes-de-uso\" >Situa&ccedil;&otilde;es de uso<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Prescricao-e-seguimento\" >Prescri&ccedil;&atilde;o e seguimento<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Contraindicacoes\" >Contraindica&ccedil;&otilde;es<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Contraindicacao-absoluta\" >Contraindica&ccedil;&atilde;o absoluta<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Contraindicacoes-relativas-e-precaucoes\" >Contraindica&ccedil;&otilde;es relativas e precau&ccedil;&otilde;es<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Farmacocinetica-e-Farmacodinamica\" >Farmacocin&eacute;tica e Farmacodin&acirc;mica<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Absorcao\" >Absor&ccedil;&atilde;o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Efeito-dos-alimentos\" >Efeito dos alimentos<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Distribuicao\" >Distribui&ccedil;&atilde;o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Metabolismo\" >Metabolismo<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Eliminacao\" >Elimina&ccedil;&atilde;o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Mecanismo-de-acao\" >Mecanismo de a&ccedil;&atilde;o<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Espectro-antimicrobiano-relevante\" >Espectro antimicrobiano relevante<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Resistencia-bacteriana\" >Resist&ecirc;ncia bacteriana<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Advertencias-e-precaucoes-da-Doxi-PEP\" >Advert&ecirc;ncias e precau&ccedil;&otilde;es da Doxi-PEP<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Resistencia-antimicrobiana\" >Resist&ecirc;ncia antimicrobiana<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Eficacia-variavel-para-gonorreia\" >Efic&aacute;cia vari&aacute;vel para gonorreia<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Populacoes-com-evidencia-limitada\" >Popula&ccedil;&otilde;es com evid&ecirc;ncia limitada<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Infeccoes-de-sifilis-de-escape\" >Infec&ccedil;&otilde;es de s&iacute;filis de escape<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Necessidade-de-rastreamento-continuo\" >Necessidade de rastreamento cont&iacute;nuo<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Interacoes-medicamentosas\" >Intera&ccedil;&otilde;es medicamentosas<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Superdosagem-ou-intoxicacao\" >Superdosagem ou intoxica&ccedil;&atilde;o<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Manejo-da-superdosagem\" >Manejo da superdosagem<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Manifestacoes-clinicas-esperadas\" >Manifesta&ccedil;&otilde;es cl&iacute;nicas esperadas<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Veja-Tambem\" >Veja Tamb&eacute;m<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Canal-do-YouTube\" >Canal do YouTube&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#Referencias-Bibliograficas\" >Refer&ecirc;ncias Bibliogr&aacute;ficas&nbsp;<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\" id=\"h-visao-geral\"><span class=\"ez-toc-section\" id=\"Visao-geral\"><\/span>Vis&atilde;o geral<span class=\"ez-toc-section-end\"><\/span><\/h2><p>O termo <strong>doxi-PEP<\/strong> refere-se especificamente &agrave; <strong>profilaxia p&oacute;s-exposi&ccedil;&atilde;o com doxiciclina<\/strong>, caracterizada pela administra&ccedil;&atilde;o do antibi&oacute;tico ap&oacute;s o evento de risco. Essa estrat&eacute;gia se diferencia da <strong>profilaxia pr&eacute;-exposi&ccedil;&atilde;o<\/strong>, que &eacute; realizada antes do contato sexual, com finalidade preventiva cont&iacute;nua.<\/p><h2 class=\"wp-block-heading\" id=\"h-indicacoes-e-dosagem\"><span class=\"ez-toc-section\" id=\"Indicacoes-e-dosagem\"><\/span>Indica&ccedil;&otilde;es e dosagem<span class=\"ez-toc-section-end\"><\/span><\/h2><p>A <strong>Doxi-PEP<\/strong> est&aacute; indicada principalmente para <strong>homens cisg&ecirc;nero que fazem sexo com homens (HSH)<\/strong> e <strong>mulheres transg&ecirc;nero<\/strong> com hist&oacute;rico recente de infec&ccedil;&atilde;o sexualmente transmiss&iacute;vel bacteriana. A estrat&eacute;gia baseia-se no uso de <strong>doxiciclina ap&oacute;s exposi&ccedil;&otilde;es sexuais de risco<\/strong>, com o objetivo de reduzir a incid&ecirc;ncia de <strong>s&iacute;filis, clam&iacute;dia e gonorreia<\/strong>.<\/p><h3 class=\"wp-block-heading\" id=\"h-indicacoes\"><span class=\"ez-toc-section\" id=\"Indicacoes\"><\/span>Indica&ccedil;&otilde;es<span class=\"ez-toc-section-end\"><\/span><\/h3><h4 class=\"wp-block-heading\" id=\"h-populacao-primaria-com-recomendacao-forte\">Popula&ccedil;&atilde;o prim&aacute;ria com recomenda&ccedil;&atilde;o forte<\/h4><ul class=\"wp-block-list\">\n<li>Indiv&iacute;duos HSH e <strong>mulheres transg&ecirc;nero<\/strong> com diagn&oacute;stico de <strong>IST bacteriana nos &uacute;ltimos 12 meses;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Aplic&aacute;vel tanto para pessoas vivendo com HIV quanto para aquelas em uso de <strong>profilaxia pr&eacute;-exposi&ccedil;&atilde;o ao HIV<\/strong>.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-populacao-expandida-com-decisao-compartilhada\">Popula&ccedil;&atilde;o expandida com decis&atilde;o compartilhada<\/h4><ul class=\"wp-block-list\">\n<li>HSH e mulheres transg&ecirc;nero sem IST recente, mas com <strong>pr&aacute;ticas sexuais associadas a maior risco;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Indiv&iacute;duos que <strong>antecipam aumento da exposi&ccedil;&atilde;o sexual<\/strong> com possibilidade de aquisi&ccedil;&atilde;o de IST.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-populacoes-com-evidencia-limitada\">Popula&ccedil;&otilde;es com evid&ecirc;ncia limitada<\/h4><ul class=\"wp-block-list\">\n<li><strong>Mulheres cisg&ecirc;nero;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Homens heterossexuais cisg&ecirc;nero;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Homens transg&ecirc;nero;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Pessoas de g&ecirc;nero diverso designadas femininas ao nascimento.<\/li>\n<\/ul><p>Nesses grupos, os dados dispon&iacute;veis s&atilde;o insuficientes para recomenda&ccedil;&atilde;o rotineira, sendo poss&iacute;vel considerar o uso de forma individualizada com <strong>decis&atilde;o compartilhada<\/strong>, especialmente diante de risco elevado.<\/p><h3 class=\"wp-block-heading\" id=\"h-dosagem-e-administracao\"><span class=\"ez-toc-section\" id=\"Dosagem-e-Administracao\"><\/span>Dosagem e Administra&ccedil;&atilde;o<span class=\"ez-toc-section-end\"><\/span><\/h3><h3 class=\"wp-block-heading\" id=\"h-posologia\"><span class=\"ez-toc-section\" id=\"Posologia\"><\/span>Posologia<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li><strong>Dose &uacute;nica de 200 mg de doxiciclina<\/strong>, independentemente da formula&ccedil;&atilde;o;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Administra&ccedil;&atilde;o <strong>o mais precocemente poss&iacute;vel ap&oacute;s a rela&ccedil;&atilde;o sexual<\/strong>, preferencialmente em at&eacute; <strong>24 horas<\/strong>, com limite m&aacute;ximo de <strong>72 horas<\/strong>.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-limite-de-dose\"><span class=\"ez-toc-section\" id=\"Limite-de-dose\"><\/span>Limite de dose<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li><strong>M&aacute;ximo de 200 mg a cada 24 horas<\/strong>, mesmo em casos de m&uacute;ltiplas exposi&ccedil;&otilde;es no mesmo per&iacute;odo.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-frequencia-de-uso\"><span class=\"ez-toc-section\" id=\"Frequencia-de-uso\"><\/span>Frequ&ecirc;ncia de uso<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Pode ser utilizada de forma repetida conforme necessidade, respeitando o limite di&aacute;rio.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-situacoes-de-uso\"><span class=\"ez-toc-section\" id=\"Situacoes-de-uso\"><\/span>Situa&ccedil;&otilde;es de uso<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Indicada ap&oacute;s <strong>sexo oral, vaginal ou anal sem preservativo.<\/strong><\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-prescricao-e-seguimento\"><span class=\"ez-toc-section\" id=\"Prescricao-e-seguimento\"><\/span>Prescri&ccedil;&atilde;o e seguimento<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Prescri&ccedil;&atilde;o geralmente baseada na <strong>frequ&ecirc;ncia de atividade sexual prevista<\/strong>, com fornecimento de doses suficientes at&eacute; a pr&oacute;xima avalia&ccedil;&atilde;o;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>A necessidade de manuten&ccedil;&atilde;o da estrat&eacute;gia deve ser <strong>reavaliada periodicamente<\/strong>, em intervalos de <strong>3 a 6 meses.<\/strong><\/li>\n<\/ul><h2 class=\"wp-block-heading\" id=\"h-contraindicacoes\"><span class=\"ez-toc-section\" id=\"Contraindicacoes\"><\/span>Contraindica&ccedil;&otilde;es<span class=\"ez-toc-section-end\"><\/span><\/h2><p>As contraindica&ccedil;&otilde;es da <strong>Doxi-PEP<\/strong> seguem aquelas estabelecidas para a <strong>doxiciclina<\/strong>, devendo ser cuidadosamente avaliadas antes da prescri&ccedil;&atilde;o.<\/p><h3 class=\"wp-block-heading\" id=\"h-contraindicacao-absoluta\"><span class=\"ez-toc-section\" id=\"Contraindicacao-absoluta\"><\/span>Contraindica&ccedil;&atilde;o absoluta<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li><strong>Hipersensibilidade &agrave;s tetraciclinas<\/strong> ou a qualquer componente da formula&ccedil;&atilde;o.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-contraindicacoes-relativas-e-precaucoes\"><span class=\"ez-toc-section\" id=\"Contraindicacoes-relativas-e-precaucoes\"><\/span>Contraindica&ccedil;&otilde;es relativas e precau&ccedil;&otilde;es<span class=\"ez-toc-section-end\"><\/span><\/h3><h4 class=\"wp-block-heading\" id=\"h-gravidez-e-desenvolvimento-dentario\">Gravidez e desenvolvimento dent&aacute;rio<\/h4><ul class=\"wp-block-list\">\n<li>Uso durante a gesta&ccedil;&atilde;o, especialmente na segunda metade, e em crian&ccedil;as at&eacute; 8 anos pode causar <strong>descolora&ccedil;&atilde;o dent&aacute;ria permanente<\/strong> e <strong>hipoplasia do esmalte;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Pode ocorrer <strong>inibi&ccedil;&atilde;o revers&iacute;vel do crescimento &oacute;sseo.<\/strong><\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-hipertensao-intracraniana\">Hipertens&atilde;o intracraniana<\/h4><ul class=\"wp-block-list\">\n<li>Associada ao uso de tetraciclinas, com manifesta&ccedil;&otilde;es como <strong>cefaleia, diplopia e altera&ccedil;&otilde;es visuais;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Maior risco em <strong>mulheres em idade f&eacute;rtil com sobrepeso<\/strong> ou hist&oacute;rico pr&eacute;vio;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Evitar associa&ccedil;&atilde;o com <strong>isotretino&iacute;na;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Pode haver risco de <strong>perda visual permanente<\/strong>, mesmo ap&oacute;s suspens&atilde;o.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-reacoes-cutaneas-graves\">Rea&ccedil;&otilde;es cut&acirc;neas graves<\/h4><ul class=\"wp-block-list\">\n<li>Incluem <strong>s&iacute;ndrome de Stevens-Johnson, necr&oacute;lise epid&eacute;rmica t&oacute;xica e DRESS;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Podem ocorrer <strong>erup&ccedil;&otilde;es medicamentosas fixas<\/strong>, com agravamento em reexposi&ccedil;&otilde;es;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Requer <strong>suspens&atilde;o imediata<\/strong> diante de sinais sugestivos.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-fotossensibilidade\">Fotossensibilidade<\/h4><ul class=\"wp-block-list\">\n<li>Pode ocorrer rea&ccedil;&atilde;o cut&acirc;nea exacerbada &agrave; luz solar;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Recomenda-se <strong>redu&ccedil;&atilde;o da exposi&ccedil;&atilde;o solar<\/strong> e medidas de fotoprote&ccedil;&atilde;o.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-diarreia-associada-a-clostridioides-difficile\">Diarreia associada a <em>Clostridioides difficile<\/em><\/h4><ul class=\"wp-block-list\">\n<li>Pode variar de diarreia leve a <strong>colite grave;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Deve ser considerada em pacientes com diarreia ap&oacute;s uso do antibi&oacute;tico;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Pode exigir suspens&atilde;o da medica&ccedil;&atilde;o.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-insuficiencia-renal\">Insufici&ecirc;ncia renal<\/h4><ul class=\"wp-block-list\">\n<li>Pode haver necessidade de <strong>ajuste de dose<\/strong> para evitar ac&uacute;mulo e toxicidade.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-sindromes-autoimunes\">S&iacute;ndromes autoimunes<\/h4><ul class=\"wp-block-list\">\n<li>Relacionadas ao uso de tetraciclinas;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Diante de manifesta&ccedil;&otilde;es compat&iacute;veis, est&aacute; indicada <strong>interrup&ccedil;&atilde;o imediata da doxiciclina.<\/strong><\/li>\n<\/ul><h2 class=\"wp-block-heading\" id=\"h-farmacocinetica-e-farmacodinamica\"><span class=\"ez-toc-section\" id=\"Farmacocinetica-e-Farmacodinamica\"><\/span>Farmacocin&eacute;tica e Farmacodin&acirc;mica<span class=\"ez-toc-section-end\"><\/span><\/h2><p>A doxiciclina apresenta perfil farmacocin&eacute;tico favor&aacute;vel para uso em <strong>profilaxia p&oacute;s-exposi&ccedil;&atilde;o<\/strong>, com <strong>absor&ccedil;&atilde;o elevada<\/strong>, ampla distribui&ccedil;&atilde;o e meia-vida prolongada.<\/p><h3 class=\"wp-block-heading\" id=\"h-absorcao\"><span class=\"ez-toc-section\" id=\"Absorcao\"><\/span>Absor&ccedil;&atilde;o<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Absor&ccedil;&atilde;o <strong>quase completa por via oral<\/strong>, com in&iacute;cio r&aacute;pido de detec&ccedil;&atilde;o plasm&aacute;tica em <strong>15 a 30 minutos;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Ap&oacute;s dose de <strong>200 mg<\/strong>:\n<ul class=\"wp-block-list\">\n<li><strong>Cmax<\/strong>: 2,6 a 3,61 &mu;g\/mL<\/li>\n\n\n\n<li><strong>Tmax<\/strong>: 2,0 a 2,6 horas<\/li>\n\n\n\n<li>Concentra&ccedil;&atilde;o em 24 horas: 0,95 a 1,45 &mu;g\/mL<\/li>\n\n\n\n<li><strong>Meia-vida<\/strong>: 15 a 25 horas<\/li>\n<\/ul>\n<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-efeito-dos-alimentos\"><span class=\"ez-toc-section\" id=\"Efeito-dos-alimentos\"><\/span>Efeito dos alimentos<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>A absor&ccedil;&atilde;o n&atilde;o sofre grande interfer&ecirc;ncia alimentar, por&eacute;m <strong>latic&iacute;nios podem reduzir a exposi&ccedil;&atilde;o sist&ecirc;mica;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Recomenda-se <strong>evitar ingest&atilde;o concomitante com leite<\/strong> ou manter intervalo de 2 a 3 horas.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-distribuicao\"><span class=\"ez-toc-section\" id=\"Distribuicao\"><\/span>Distribui&ccedil;&atilde;o<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Alta lipossolubilidade, com <strong>ampla penetra&ccedil;&atilde;o tecidual;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Liga&ccedil;&atilde;o proteica superior a 90%;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Presen&ccedil;a em f&iacute;gado, medula &oacute;ssea e ba&ccedil;o;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Atravessa a placenta e &eacute; detectada no leite materno;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Pode formar dep&oacute;sitos em <strong>ossos e dentes em desenvolvimento.<\/strong><\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-metabolismo\"><span class=\"ez-toc-section\" id=\"Metabolismo\"><\/span>Metabolismo<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Metab&oacute;litos n&atilde;o bem definidos;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>F&aacute;rmacos indutores enzim&aacute;ticos podem <strong>reduzir a meia-vida.<\/strong><\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-eliminacao\"><span class=\"ez-toc-section\" id=\"Eliminacao\"><\/span>Elimina&ccedil;&atilde;o<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Predominantemente pelo <strong>trato gastrointestinal<\/strong>, com menor excre&ccedil;&atilde;o renal;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Cerca de <strong>40% excretado na urina em 72 horas<\/strong> em fun&ccedil;&atilde;o renal normal;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Em insufici&ecirc;ncia renal grave, excre&ccedil;&atilde;o renal reduzida sem altera&ccedil;&atilde;o relevante da meia-vida;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Hemodi&aacute;lise n&atilde;o altera significativamente a depura&ccedil;&atilde;o;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Parte da droga &eacute; eliminada pelas fezes ap&oacute;s secre&ccedil;&atilde;o biliar.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-mecanismo-de-acao\"><span class=\"ez-toc-section\" id=\"Mecanismo-de-acao\"><\/span>Mecanismo de a&ccedil;&atilde;o<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Inibi&ccedil;&atilde;o da s&iacute;ntese proteica bacteriana por liga&ccedil;&atilde;o &agrave; <strong>subunidade ribossomal 30S;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>A&ccedil;&atilde;o predominantemente <strong>bacteriost&aacute;tica.<\/strong><\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-espectro-antimicrobiano-relevante\"><span class=\"ez-toc-section\" id=\"Espectro-antimicrobiano-relevante\"><\/span>Espectro antimicrobiano relevante<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Atividade contra:\n<ul class=\"wp-block-list\">\n<li><strong><em>Treponema pallidum<\/em>;<\/strong><\/li>\n\n\n\n<li><strong><em>Chlamydia trachomatis<\/em>;<\/strong><\/li>\n\n\n\n<li><strong><em>Neisseria gonorrhoeae<\/em><\/strong>, com limita&ccedil;&atilde;o devido &agrave; resist&ecirc;ncia.<\/li>\n<\/ul>\n<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-resistencia-bacteriana\"><span class=\"ez-toc-section\" id=\"Resistencia-bacteriana\"><\/span>Resist&ecirc;ncia bacteriana<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Pode ocorrer <strong>resist&ecirc;ncia cruzada com outras tetraciclinas;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>A resist&ecirc;ncia da <strong>Neisseria gonorrhoeae<\/strong> &eacute; vari&aacute;vel e representa limita&ccedil;&atilde;o cl&iacute;nica relevante.<\/li>\n<\/ul><h2 class=\"wp-block-heading\" id=\"h-advertencias-e-precaucoes-da-doxi-pep\"><span class=\"ez-toc-section\" id=\"Advertencias-e-precaucoes-da-Doxi-PEP\"><\/span>Advert&ecirc;ncias e precau&ccedil;&otilde;es da Doxi-PEP<span class=\"ez-toc-section-end\"><\/span><\/h2><p>A utiliza&ccedil;&atilde;o da <strong>Doxi-PEP<\/strong> exige avalia&ccedil;&atilde;o criteriosa, especialmente devido a implica&ccedil;&otilde;es relacionadas &agrave; <strong>resist&ecirc;ncia antimicrobiana<\/strong>, efic&aacute;cia vari&aacute;vel e necessidade de monitoramento cl&iacute;nico cont&iacute;nuo.<\/p><h3 class=\"wp-block-heading\" id=\"h-resistencia-antimicrobiana\"><span class=\"ez-toc-section\" id=\"Resistencia-antimicrobiana\"><\/span>Resist&ecirc;ncia antimicrobiana<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Principal preocupa&ccedil;&atilde;o associada ao uso da estrat&eacute;gia;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Impacto potencial sobre <strong><em>Neisseria gonorrhoeae<\/em><\/strong> e tamb&eacute;m sobre o <strong>microbioma<\/strong>, incluindo microrganismos como <strong><em>Staphylococcus<\/em>;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Necessidade de uso direcionado e criterioso;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Recomendado <strong>monitoramento cont&iacute;nuo de padr&otilde;es de resist&ecirc;ncia<\/strong> em n&iacute;vel individual e populacional.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-eficacia-variavel-para-gonorreia\"><span class=\"ez-toc-section\" id=\"Eficacia-variavel-para-gonorreia\"><\/span>Efic&aacute;cia vari&aacute;vel para gonorreia<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Atividade contra <strong><em>N. gonorrhoeae<\/em><\/strong> &eacute; inconsistente;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Influenciada por <strong>n&iacute;veis regionais de resist&ecirc;ncia &agrave; tetraciclina;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Redu&ccedil;&atilde;o de efic&aacute;cia quando comparada a outros pat&oacute;genos alvo, como s&iacute;filis e clam&iacute;dia.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-populacoes-com-evidencia-limitada-0\"><span class=\"ez-toc-section\" id=\"Populacoes-com-evidencia-limitada\"><\/span>Popula&ccedil;&otilde;es com evid&ecirc;ncia limitada<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Aus&ecirc;ncia de recomenda&ccedil;&otilde;es formais para:\n<ul class=\"wp-block-list\">\n<li><strong>Mulheres cisg&ecirc;nero<\/strong><\/li>\n\n\n\n<li><strong>Homens heterossexuais cisg&ecirc;nero<\/strong><\/li>\n\n\n\n<li><strong>Homens transg&ecirc;nero<\/strong><\/li>\n\n\n\n<li>Pessoas de g&ecirc;nero diverso designadas femininas ao nascimento.<\/li>\n<\/ul>\n<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Uso deve ser individualizado, com <strong>decis&atilde;o compartilhada<\/strong>, considerando risco de exposi&ccedil;&atilde;o<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-infeccoes-de-sifilis-de-escape\"><span class=\"ez-toc-section\" id=\"Infeccoes-de-sifilis-de-escape\"><\/span>Infec&ccedil;&otilde;es de s&iacute;filis de escape<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Possibilidade de infec&ccedil;&otilde;es com <strong>apresenta&ccedil;&atilde;o cl&iacute;nica atenuada;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Potencial altera&ccedil;&atilde;o em testes sorol&oacute;gicos, como <strong>RPR<\/strong>, com respostas menos evidentes;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Dados ainda limitados sobre relev&acirc;ncia cl&iacute;nica desse fen&ocirc;meno.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-necessidade-de-rastreamento-continuo\"><span class=\"ez-toc-section\" id=\"Necessidade-de-rastreamento-continuo\"><\/span>Necessidade de rastreamento cont&iacute;nuo<span class=\"ez-toc-section-end\"><\/span><\/h3><ul class=\"wp-block-list\">\n<li>Indiv&iacute;duos em uso de Doxi-PEP devem realizar <strong>rastreamento regular para ISTs;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Intervalos recomendados de <strong>3 a 6 meses<\/strong>, ajustados conforme comportamento sexual;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Inclui testagem de <strong>s&iacute;tios anat&ocirc;micos expostos<\/strong> e sorologia para s&iacute;filis;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Abordagem sistem&aacute;tica permite detec&ccedil;&atilde;o precoce e manejo adequado de infec&ccedil;&otilde;es incidentes.<\/li>\n<\/ul><h2 class=\"wp-block-heading\" id=\"h-interacoes-medicamentosas\"><span class=\"ez-toc-section\" id=\"Interacoes-medicamentosas\"><\/span>Intera&ccedil;&otilde;es medicamentosas<span class=\"ez-toc-section-end\"><\/span><\/h2><figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Tipo de Intera&ccedil;&atilde;o<\/th><th>Medicamentos<\/th><th>Efeito<\/th><th>Manejo<\/th><\/tr><\/thead><tbody><tr><td><strong>Diminui&ccedil;&atilde;o da absor&ccedil;&atilde;o<\/strong><\/td><td>Anti&aacute;cidos (Al, Ca, Mg), ferro, bismuto<\/td><td>&darr; Absor&ccedil;&atilde;o de doxiciclina<\/td><td>Separar por 2 a 3 horas<\/td><\/tr><tr><td><strong>Diminui&ccedil;&atilde;o da meia-vida<\/strong><\/td><td>Barbit&uacute;ricos, carbamazepina, fenito&iacute;na, rifampicina<\/td><td>&darr; Concentra&ccedil;&atilde;o de doxiciclina<\/td><td>Considerar ajuste de dose<\/td><\/tr><tr><td><strong>Efeito anticoagulante<\/strong><\/td><td>Varfarina, outros anticoagulantes<\/td><td>&uarr; Efeito anticoagulante<\/td><td>Monitorar INR e ajustar dose<\/td><\/tr><tr><td><strong>Antagonismo antibi&oacute;tico<\/strong><\/td><td>Penicilinas<\/td><td>Interfer&ecirc;ncia na a&ccedil;&atilde;o bactericida<\/td><td>Evitar uso concomitante<\/td><\/tr><tr><td><strong>Contraceptivos<\/strong><\/td><td>Contraceptivos orais<\/td><td>Poss&iacute;vel &darr; efic&aacute;cia<\/td><td>Considerar m&eacute;todo adicional<\/td><\/tr><tr><td><strong>Toxicidade renal<\/strong><\/td><td>Metoxiflurano<\/td><td>Risco de nefrotoxicidade grave<\/td><td>Uso contraindicado<\/td><\/tr><tr><td><strong>Hipertens&atilde;o intracraniana<\/strong><\/td><td>Isotretino&iacute;na<\/td><td>&uarr; Risco de pseudotumor cerebral<\/td><td>Evitar uso concomitante<\/td><\/tr><tr><td><strong>Antirretrovirais<\/strong><\/td><td>IPs, NNRTIs, INSTIs<\/td><td>Nenhuma intera&ccedil;&atilde;o conhecida<\/td><td>Nenhum ajuste necess&aacute;rio<\/td><\/tr><\/tbody><\/table><\/figure><h2 class=\"wp-block-heading\" id=\"h-superdosagem-ou-intoxicacao\"><span class=\"ez-toc-section\" id=\"Superdosagem-ou-intoxicacao\"><\/span>Superdosagem ou intoxica&ccedil;&atilde;o<span class=\"ez-toc-section-end\"><\/span><\/h2><p>A superdosagem de <strong>doxiciclina<\/strong> no contexto da <strong>Doxi-PEP<\/strong> n&atilde;o possui ant&iacute;doto espec&iacute;fico, sendo o manejo baseado em <strong>tratamento sintom&aacute;tico e medidas de suporte cl&iacute;nico<\/strong>.<\/p><h3 class=\"wp-block-heading\" id=\"h-manejo-da-superdosagem\"><span class=\"ez-toc-section\" id=\"Manejo-da-superdosagem\"><\/span>Manejo da superdosagem<span class=\"ez-toc-section-end\"><\/span><\/h3><h4 class=\"wp-block-heading\" id=\"h-conduta-inicial\">Conduta inicial<\/h4><ul class=\"wp-block-list\">\n<li><strong>Suspens&atilde;o imediata da medica&ccedil;&atilde;o;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Institui&ccedil;&atilde;o de <strong>tratamento sintom&aacute;tico;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Ado&ccedil;&atilde;o de <strong>medidas de suporte conforme o quadro cl&iacute;nico.<\/strong><\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-dialise\">Di&aacute;lise<\/h4><ul class=\"wp-block-list\">\n<li>A di&aacute;lise <strong>n&atilde;o &eacute; eficaz<\/strong> na remo&ccedil;&atilde;o da doxiciclina;<\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li>Isso se deve &agrave; <strong>alta liga&ccedil;&atilde;o &agrave;s prote&iacute;nas plasm&aacute;ticas<\/strong> e ao predom&iacute;nio de elimina&ccedil;&atilde;o pelo trato gastrointestinal.<\/li>\n<\/ul><h3 class=\"wp-block-heading\" id=\"h-manifestacoes-clinicas-esperadas\"><span class=\"ez-toc-section\" id=\"Manifestacoes-clinicas-esperadas\"><\/span>Manifesta&ccedil;&otilde;es cl&iacute;nicas esperadas<span class=\"ez-toc-section-end\"><\/span><\/h3><p>Embora n&atilde;o haja descri&ccedil;&atilde;o espec&iacute;fica para superdosagem na bula, os achados s&atilde;o extrapolados a partir dos efeitos adversos conhecidos das tetraciclinas.<\/p><h4 class=\"wp-block-heading\" id=\"h-sintomas-gastrointestinais\">Sintomas gastrointestinais<\/h4><ul class=\"wp-block-list\">\n<li><strong>N&aacute;useas e v&ocirc;mitos;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Diarreia;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Dor epig&aacute;strica;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Anorexia;<\/strong><\/li>\n<\/ul><ul class=\"wp-block-list\">\n<li><strong>Disfagia.<\/strong><\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-alteracoes-renais\">Altera&ccedil;&otilde;es renais<\/h4><ul class=\"wp-block-list\">\n<li>Eleva&ccedil;&atilde;o de <strong>ureia (BUN)<\/strong>, possivelmente relacionada &agrave; dose.<\/li>\n<\/ul><h4 class=\"wp-block-heading\" id=\"h-hepatotoxicidade\">Hepatotoxicidade<\/h4><ul class=\"wp-block-list\">\n<li>Pode ocorrer, especialmente em pacientes com <strong>comprometimento renal associado.<\/strong><\/li>\n<\/ul><p>O acompanhamento cl&iacute;nico deve ser direcionado &agrave; identifica&ccedil;&atilde;o precoce de complica&ccedil;&otilde;es e &agrave; manuten&ccedil;&atilde;o da estabilidade hemodin&acirc;mica e metab&oacute;lica.<\/p><p><strong><em>Venha fazer parte da maior plataforma de Medicina do Brasil! O Estrat&eacute;gia MED possui os materiais mais atualizados e cursos ministrados por especialistas na &aacute;rea. N&atilde;o perca a oportunidade de elevar seus estudos, inscreva-se agora e comece a construir um caminho de excel&ecirc;ncia na medicina!<\/em><\/strong>&nbsp;<\/p><h2 class=\"wp-block-heading\" id=\"h-veja-tambem\"><span class=\"ez-toc-section\" id=\"Veja-Tambem\"><\/span>Veja Tamb&eacute;m<span class=\"ez-toc-section-end\"><\/span><\/h2><ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-de-prep-injetavel-com-lenacapavir\/\">Resumo de PrEP injet&aacute;vel com Lenacapavir<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/doencas\/resumo-de-hiv-na-gestacao-diagnostico-tratamento-e-mais\/\">Resumo de HIV na gesta&ccedil;&atilde;o: diagn&oacute;stico, tratamento e mais!<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/doencas\/resumo-de-gemelaridade-diagnostico-tratamento-e-mais\/\">Resumo de gemelaridade: diagn&oacute;stico, tratamento e mais!<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/procedimentos\/resumo-de-parto-instrumentalizado-forceps-diagnostico-tratamento-e-mais\/\">Resumo de parto instrumentalizado (f&oacute;rceps): diagn&oacute;stico, tratamento e mais!<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/doencas\/resumo-de-sindrome-hellp-diagnostico-tratamento-e-mais\/\">Resumo de s&iacute;ndrome hellp: diagn&oacute;stico, tratamento e mais!<\/a>&nbsp;<\/li>\n\n\n\n<li><a href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/doencas\/resumo-de-hipertensao-gestacional-diagnostico-tratamento-e-mais\/\">Resumo de hipertens&atilde;o gestacional: diagn&oacute;stico, tratamento e mais!<\/a><\/li>\n<\/ul><h2 class=\"wp-block-heading\" id=\"h-canal-do-youtube-nbsp\"><span class=\"ez-toc-section\" id=\"Canal-do-YouTube\"><\/span>Canal do YouTube&nbsp;<span class=\"ez-toc-section-end\"><\/span><\/h2><ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.youtube.com\/@EstrategiaMED\" target=\"_blank\" rel=\"noopener noreferrer\">YouTube do Estrat&eacute;gia MED<\/a><\/li>\n<\/ul><h2 class=\"wp-block-heading\" id=\"h-referencias-bibliograficas-nbsp\"><span class=\"ez-toc-section\" id=\"Referencias-Bibliograficas\"><\/span>Refer&ecirc;ncias Bibliogr&aacute;ficas&nbsp;<span class=\"ez-toc-section-end\"><\/span><\/h2><ol class=\"wp-block-list\">\n<li>BACHMANN, L. H.; BARBEE, L. A.; CHAN, P.; et al. <strong>CDC clinical guidelines on the use of doxycycline postexposure prophylaxis for bacterial sexually transmitted infection prevention<\/strong>, United States, 2024. <em>MMWR Recommendations and Reports: Morbidity and Mortality Weekly Report<\/em>, 2024.<\/li>\n<\/ol><ol start=\"2\" class=\"wp-block-list\">\n<li>HORBERG, M.; THOMPSON, M.; AGWU, A.; et al. <strong>Primary care guidance for providers of care for persons with human immunodeficiency virus: 2024 update by the HIV Medicine Association of the Infectious Diseases Society of America<\/strong>. <em>Clinical Infectious Diseases<\/em>, 2024.<\/li>\n<\/ol><ol start=\"3\" class=\"wp-block-list\">\n<li>PETERS, R. P. H.; GRINSZTEJN, B.; CELUM, C.; et al. <strong>Innovations in the biomedical prevention, diagnosis, and service delivery of HIV and other sexually transmitted infections<\/strong>. <em>Lancet<\/em>, 2025.<\/li>\n<\/ol><p>\n\n\n\n<a id=\"cta\" class=\"cta-imagem\" href=\"https:\/\/med.estrategia.com\/curso\/banco-de-questes-resumos-estrategicos-anual\/\" target=\"blank\">\n                <img decoding=\"async\" width=\"100%\" src=\"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2025\/08\/banco_questoes.png\" alt=\"banco_questoes\" title=\"banco_questoes\">\n        <\/a>\n<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"Ol&aacute;, querido doutor e doutora! A Doxi-PEP representa uma estrat&eacute;gia de profilaxia p&oacute;s-exposi&ccedil;&atilde;o voltada &agrave; redu&ccedil;&atilde;o de infec&ccedil;&otilde;es&hellip;\n","protected":false},"author":46,"featured_media":108584,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"wl_entities_gutenberg":"","footnotes":""},"categories":[33,306],"tags":[1662],"wl_entity_type":[199],"class_list":{"0":"post-108583","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-conteudos-gratis","8":"category-farmacos","9":"tag-doxi-pep","10":"wl_entity_type-article"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v26.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!<\/title>\n<meta name=\"description\" content=\"O termo doxi-PEP refere-se \u00e0 profilaxia p\u00f3s-exposi\u00e7\u00e3o com doxiciclina, caracterizada pela administra\u00e7\u00e3o do antibi\u00f3tico ap\u00f3s evento de risco.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!\" \/>\n<meta property=\"og:description\" content=\"O termo doxi-PEP refere-se \u00e0 profilaxia p\u00f3s-exposi\u00e7\u00e3o com doxiciclina, caracterizada pela administra\u00e7\u00e3o do antibi\u00f3tico ap\u00f3s evento de risco.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/\" \/>\n<meta property=\"og:site_name\" content=\"Estrat\u00e9gia MED\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/estrategiamed1\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-23T20:52:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-31T14:16:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1585\" \/>\n\t<meta property=\"og:image:height\" content=\"1052\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Pablo Fernandes\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@estrategiamed_\" \/>\n<meta name=\"twitter:site\" content=\"@estrategiamed_\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Pablo Fernandes\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/\",\"url\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/\",\"name\":\"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!\",\"isPartOf\":{\"@id\":\"https:\/\/med.estrategia.com\/portal\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg\",\"datePublished\":\"2026-03-23T20:52:27+00:00\",\"dateModified\":\"2026-03-31T14:16:18+00:00\",\"author\":{\"@id\":\"https:\/\/med.estrategia.com\/portal\/#\/schema\/person\/67a72aa9c51ed5919796767d808606b4\"},\"description\":\"O termo doxi-PEP refere-se \u00e0 profilaxia p\u00f3s-exposi\u00e7\u00e3o com doxiciclina, caracterizada pela administra\u00e7\u00e3o do antibi\u00f3tico ap\u00f3s evento de risco.\",\"breadcrumb\":{\"@id\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#primaryimage\",\"url\":\"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg\",\"contentUrl\":\"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg\",\"width\":1585,\"height\":1052},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/med.estrategia.com\/portal\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Conte\u00fados Gr\u00e1tis\",\"item\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"F\u00e1rmacos\",\"item\":\"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/med.estrategia.com\/portal\/#website\",\"url\":\"https:\/\/med.estrategia.com\/portal\/\",\"name\":\"Estrat\u00e9gia MED\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/med.estrategia.com\/portal\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/med.estrategia.com\/portal\/#\/schema\/person\/67a72aa9c51ed5919796767d808606b4\",\"name\":\"Pablo Fernandes\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\/\/med.estrategia.com\/portal\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2025\/07\/DSC_0059-1-150x150.jpg\",\"contentUrl\":\"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2025\/07\/DSC_0059-1-150x150.jpg\",\"caption\":\"Pablo Fernandes\"},\"description\":\"R1 em Medicina de Fam\u00edlia e Comunidade, mineiro e apaixonado por Jesus.\",\"sameAs\":[\"https:\/\/www.instagram.com\/pablowiil\/\"],\"url\":\"https:\/\/med.estrategia.com\/portal\/author\/pablo-souza\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!","description":"O termo doxi-PEP refere-se \u00e0 profilaxia p\u00f3s-exposi\u00e7\u00e3o com doxiciclina, caracterizada pela administra\u00e7\u00e3o do antibi\u00f3tico ap\u00f3s evento de risco.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/","og_locale":"pt_BR","og_type":"article","og_title":"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!","og_description":"O termo doxi-PEP refere-se \u00e0 profilaxia p\u00f3s-exposi\u00e7\u00e3o com doxiciclina, caracterizada pela administra\u00e7\u00e3o do antibi\u00f3tico ap\u00f3s evento de risco.","og_url":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/","og_site_name":"Estrat\u00e9gia MED","article_publisher":"https:\/\/www.facebook.com\/estrategiamed1","article_published_time":"2026-03-23T20:52:27+00:00","article_modified_time":"2026-03-31T14:16:18+00:00","og_image":[{"width":1585,"height":1052,"url":"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg","type":"image\/jpeg"}],"author":"Pablo Fernandes","twitter_card":"summary_large_image","twitter_creator":"@estrategiamed_","twitter_site":"@estrategiamed_","twitter_misc":{"Escrito por":"Pablo Fernandes","Est. tempo de leitura":"9 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/","url":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/","name":"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!","isPartOf":{"@id":"https:\/\/med.estrategia.com\/portal\/#website"},"primaryImageOfPage":{"@id":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#primaryimage"},"image":{"@id":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#primaryimage"},"thumbnailUrl":"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg","datePublished":"2026-03-23T20:52:27+00:00","dateModified":"2026-03-31T14:16:18+00:00","author":{"@id":"https:\/\/med.estrategia.com\/portal\/#\/schema\/person\/67a72aa9c51ed5919796767d808606b4"},"description":"O termo doxi-PEP refere-se \u00e0 profilaxia p\u00f3s-exposi\u00e7\u00e3o com doxiciclina, caracterizada pela administra\u00e7\u00e3o do antibi\u00f3tico ap\u00f3s evento de risco.","breadcrumb":{"@id":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/"]}]},{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#primaryimage","url":"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg","contentUrl":"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2026\/03\/iScreen-Shoter-Google-Chrome-260323175022.jpg","width":1585,"height":1052},{"@type":"BreadcrumbList","@id":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/med.estrategia.com\/portal\/"},{"@type":"ListItem","position":2,"name":"Conte\u00fados Gr\u00e1tis","item":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/"},{"@type":"ListItem","position":3,"name":"F\u00e1rmacos","item":"https:\/\/med.estrategia.com\/portal\/conteudos-gratis\/farmacos\/"},{"@type":"ListItem","position":4,"name":"Resumo sobre Doxi-PEP: indica\u00e7\u00f5es, farmacologia e mais!"}]},{"@type":"WebSite","@id":"https:\/\/med.estrategia.com\/portal\/#website","url":"https:\/\/med.estrategia.com\/portal\/","name":"Estrat\u00e9gia MED","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/med.estrategia.com\/portal\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":"Person","@id":"https:\/\/med.estrategia.com\/portal\/#\/schema\/person\/67a72aa9c51ed5919796767d808606b4","name":"Pablo Fernandes","image":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/med.estrategia.com\/portal\/#\/schema\/person\/image\/","url":"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2025\/07\/DSC_0059-1-150x150.jpg","contentUrl":"https:\/\/med.estrategia.com\/portal\/wp-content\/uploads\/2025\/07\/DSC_0059-1-150x150.jpg","caption":"Pablo Fernandes"},"description":"R1 em Medicina de Fam\u00edlia e Comunidade, mineiro e apaixonado por Jesus.","sameAs":["https:\/\/www.instagram.com\/pablowiil\/"],"url":"https:\/\/med.estrategia.com\/portal\/author\/pablo-souza\/"}]}},"_wl_alt_label":[],"wl:entity_url":"\/post\/resumo-sobre-doxi-pep-indicacoes-farmacologia-e-mais-108583","_links":{"self":[{"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/posts\/108583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/users\/46"}],"replies":[{"embeddable":true,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/comments?post=108583"}],"version-history":[{"count":4,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/posts\/108583\/revisions"}],"predecessor-version":[{"id":108831,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/posts\/108583\/revisions\/108831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/media\/108584"}],"wp:attachment":[{"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/media?parent=108583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/categories?post=108583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/tags?post=108583"},{"taxonomy":"wl_entity_type","embeddable":true,"href":"https:\/\/med.estrategia.com\/portal\/wp-json\/wp\/v2\/wl_entity_type?post=108583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}